2012戴芳澜学术论坛（四）: Mini Symposium of Fungal Genomics

时  间：8月13日(星期一)上午9:00-11:20

地  点：微生物所A203会议室

主持人：李少杰 研究员

日程安排：

报告摘要:
Light is a major environmental signal for most life on earth.  Fungal genomes encode several proteins capable of binding chromophores with the ability to harvest light energy as well as proteins that can interact with primary photoreceptors or further propagate the light signal. The best understood fungal photoreceptors are the evolutionarily conserved white collar-1 (WC-1) and white collar-2 (WC-2) proteins that form the White Collar Complex (WCC), the primary blue-light photoreceptor and the transcription factor complex that initiates light-regulated transcriptional responses, and the related Vivid (VVD) protein in Neurospora crassa. Close to 6% of Neurospora genes are expressed in response to a light stimulus in a temporally regulated cascade that includes several transcription factors, culminating within 24 hours in full asexual development. Photoadaptation is the ability to attenuate a light response upon prolonged light exposure while remaining sensitive to escalating changes in light intensity. In Neurospora, VVD, a small LOV domain containing blue-light photoreceptor protein, is responsible for most if not all photoadaptation responses. We have found a physical interaction between VVD and the WCC and that nuclear localization of VVD does not require light.

报告人简介：
Jennifer Loros
(Ph.D.，Professor，Dartmouth College)
Jennifer earned a BA and PhD in biology at the University of California, Santa Cruz. She then came to Dartmouth Medical School as a post-doc, joining the faculty in 1988. Her work is focused on the genetic dissection of the circadian clock, clock-controlled gene expression and fungal photobiology.

Jay Dunlap
(Member of United States National Academy of Sciences, Professor and chair, department of genetics, Dartmouth College)
Jay earned dual BS degrees from the University of Washington and a PhD in biology from Harvard, then carried out postdoctoral research in molecular genetics at the University of California, Santa Cruz. He joined the DMS faculty in 1984. He has worked on the molecular basis of circadian rhythms for several decades, chiefly using the Neurospora model but within the past decade also using mice and mammalian cell culture models.